Find NHLBI Clinical Trials and Studies
Search selected NHLBI-supported and by condition, location, or age group. You can also view the complete list of NHLBI-funded studies at ClinicalTrials.gov.
Showing 21 - 30 out of 271 results
Recruiting
Florida
Texas
The overall objective of research is to test, adapt, refine and validate the HEMOTAG® system to be used outside the usual medical care environments to reduce hospital readmissions.
Adult, Older Adult
Recruiting
Tennessee
Ventilated pediatric patients are frequently over-sedated and the majority suffer from delirium, a form of acute brain dysfunction that is an independent predictor of increased risk of dying, length of stay, and costs. Universally prescribed sedative medications-the GABA-ergic benzodiazepines-worsen this brain organ dysfunction and independently prolong duration of ventilation and ICU stay, and the available alternative sedation regimen using dexmedetomidine, an alpha-2 agonist, has been shown to be superior to benzodiazepines in adults, and may mechanistically impact outcomes through positive effects on innate immunity, bacterial clearance, apoptosis, cognition and delirium. The mini-MENDS trial will compare dexmedetomidine and midazolam, and determine the best sedative medication to reduce delirium and improve duration of ventilation, and functional, psychiatric, and cognitive recovery in our most vulnerable patients-survivors of pediatric critical illness.
Child
Recruiting
Massachusetts
Are you an adult with primary light chain amyloidosis? Researchers in this study are investigating new ways to look at the heart to identify when it is not working properly. You may be able to participate if you are at least 18 years old and have been diagnosed with primary light chain amyloidosis. This study is taking place in Boston, Massachusetts.
Adult, Older Adult
Recruiting
The objective of the ALA-LHC is to establish a national cohort of young adults for the purpose of defining lung health and developing targets to intercept chronic lung disease at its earliest stages.
Adult
Accepting Healthy Volunteers
Not yet recruiting
Georgia
Maryland
Do you have heart disease?
This study is looking to improve the quality of heart CT scans by using new methods to create the images. You may be able to participate in the study if you are 18 years old or older, have heart disease, and have been told by your doctor that you need a CT scan. This study is taking place at the National Institutes of Health Clinical Center in Bethesda, Maryland.
Adult, Older Adult
Recruiting
Maryland
Virginia
Are you in need of a heart or lung transplant or have you had one in the past 3 months?
Have you undergone a lung or heart transplant in the past 3 months or are you a candidate for heart or lung transplant? Some people with advanced heart and lung disease have heart and lung transplants but these new organs are often rejected. When this happens, patients must have repeated biopsies, which are invasive and expensive. Researchers in this clinical study want to see if a blood test can predict organ rejection and take the place of biopsies. To participate, you must be 18 to 80 years old and be a candidate for heart or lung transplant or have had a heart or lung transplant no more than three months ago. The study is taking place in Bethesda, Maryland, at the NIH Clinical Center, as well as in Baltimore, Maryland, and Falls Church, Virginia.
All Ages
Recruiting
Connecticut
Have you been admitted to the Intensive Care Unit (ICU)?
Have you been admitted to the Intensive Care Unit (ICU)? Many ICU patients experience profound sleep and circadian rhythm disruption. This study will test how light, feeding, mobility, and sleep may normalize circadian rhythms and improve sleep and metabolism. You may be able to participate if you are 18 years old or older. This study is recruiting in New Haven, Connecticut.
Adult, Older Adult
Recruiting
Pennsylvania
Do you have high blood pressure? If so, you may be able to participate in a clinical research study. Researchers are testing a home-based blood pressure monitoring program that provides health education, guidance, monitoring, and patient coaching to people who live in rural areas. You must be at least 18 years old to participate and be taking medication for high blood pressure. The study is taking place in Pittsburgh, Pennsylvania.
Adult, Older Adult
Recruiting
Tennessee
Are you an adult with pulmonary arterial hypertension?
Are you an adult with pulmonary arterial hypertension? Researchers want to learn more about how well people with pulmonary arterial hypertension are able to exercise. To participate, you must be 18 years old and be able to walk for at least 6 minutes. The study is taking place in Nashville, Tennessee.
Adult, Older Adult
Recruiting
Pennsylvania
Does your child or someone you know have pediatric pulmonary hypertension?
Does your child or someone you know have pediatric pulmonary hypertension? This study is using a wearable monitoring device to promote physical activity in a 16-week intervention. To participate in this study, the child must be 8 to 18 years old and have a Wi-Fi-enabled mobile device in the family, capable of receiving text messages. This study is located in Philadelphia, Pennsylvania.
Child, Adult